Levinson S, Vincent K A
Oregon Health Sciences University, Portland, USA.
J Pediatr Hematol Oncol. 1997 May-Jun;19(3):251-3. doi: 10.1097/00043426-199705000-00014.
The purpose of this report is to present a case of multifocal osteosarcoma in a patient with Fanconi anemia.
A nine year old girl with known Fanconi anemia presented with a pathologic femur fracture. Imaging studies confirmed soft tissue and bony involvement in the femur, ipsilateral tibia, and possibly contralateral femur.
Biopsy and subsequent amputation confirmed the presence of classic osteosarcoma in the involved femur and ipsilateral tibia. The patient died seven months later of pulmonary failure secondary to metastases.
Fanconi anemia is known to be associated with malignancies such as leukemias. We report a new association of Fanconi anemia with osteosarcoma.
本报告旨在介绍一例患有范可尼贫血的多灶性骨肉瘤患者。
一名已知患有范可尼贫血的9岁女孩因病理性股骨骨折就诊。影像学检查证实股骨、同侧胫骨以及可能的对侧股骨存在软组织和骨受累情况。
活检及后续截肢证实受累的股骨和同侧胫骨存在典型骨肉瘤。患者七个月后死于转移继发的肺功能衰竭。
已知范可尼贫血与白血病等恶性肿瘤有关。我们报告了范可尼贫血与骨肉瘤的一种新关联。
