Asero R
Ambulatorio di Allergologia, Ospedale Caduti Bollatesi, Milan, Italy.
Allergy. 1997 May;52(5):560-4. doi: 10.1111/j.1398-9995.1997.tb02600.x.
A large clinical/serologic study was carried out to determine the prevalence of Apiaceae (carrot, celery, and fennel) hypersensitivity in patients with birch pollen allergy, and to investigate its relationship with apple and hazelnut allergy and with birch pollen-specific IgE levels. A total of 196 birch pollen-hypersensitive patients with oral allergy syndrome (OAS) caused by different vegetable foods were examined in the cross-sectional part of the study. Of this total, 195 patients had apple and/or hazelnut allergy, and 103 had Apiaceae sensitivity; only one patient had Apiaceae allergy alone. Apiaceae-positive patients showed significantly higher birch pollen-specific IgE levels than negative ones (median 13 vs 7 AU/ml; P < 0.0001). The prospective part of the study was performed on 103 birch pollen-hypersensitive patients who were OAS-free at the time of the first visit and were periodically followed-up for OAS. Patients who developed Apiaceae sensitivity showed much higher birch-specific IgE levels than patients who developed apple/hazelnut allergy only (median 15.5 vs 8.5 AU/ml; P < 0.05), whereas those who remained OAS-free showed the lowest specific IgE levels (median 5 AU/ml). This study suggests that most Apiaceae determinants cross-react with apple or hazelnut determinants, whereas only some apple or hazelnut determinants cross-react with Apiaceae-allergenic determinants; moreover, it shows that birch-specific IgE levels heavily influence the onset of OAS as a whole, and probably play a critical role in the development of allergies to distinct vegetable foods as well.
开展了一项大型临床/血清学研究，以确定桦树花粉过敏患者中伞形科（胡萝卜、芹菜和茴香）过敏的患病率，并研究其与苹果和榛子过敏以及桦树花粉特异性IgE水平的关系。在该研究的横断面部分，共检查了196例因不同蔬菜食物引起口腔过敏综合征（OAS）的桦树花粉过敏患者。其中，195例患者有苹果和/或榛子过敏，103例有伞形科过敏；仅1例患者仅有伞形科过敏。伞形科阳性患者的桦树花粉特异性IgE水平显著高于阴性患者（中位数分别为13和7 AU/ml；P<0.0001）。该研究的前瞻性部分对103例首次就诊时无OAS且定期随访OAS的桦树花粉过敏患者进行。出现伞形科过敏的患者的桦树特异性IgE水平远高于仅出现苹果/榛子过敏的患者（中位数分别为15.5和8.5 AU/ml；P<0.05），而那些仍无OAS的患者的特异性IgE水平最低（中位数为5 AU/ml）。这项研究表明，大多数伞形科决定簇与苹果或榛子决定簇发生交叉反应，而只有一些苹果或榛子决定簇与伞形科过敏原决定簇发生交叉反应；此外，研究表明，桦树特异性IgE水平对整体OAS的发病有重大影响，可能在对不同蔬菜食物过敏的发展中也起关键作用。
