Goldsmith H H, Gottesman I I, Lemery K S
Department of Psychology, University of Wisconsin-Madison 53706, USA.
Dev Psychopathol. 1997 Spring;9(2):365-87. doi: 10.1017/s0954579497002095.
We evaluate the usefulness of 11 key epigenetic concepts from the behavior genetic research paradigm for advancing the field of developmental psychopathology. Key assumptions, empirical examples, and caveats in interpreting results are presented. We emphasize the usefulness of incorporating both dimensional (e.g., temperament trait) and categorical (e.g., diagnosis) variables, environmental measures, direct behavioral assessments, and multiple, theoretically relevant occasions of study into classic twin and family studies. We highlight contemporary techniques for identifying specific chromosomal regions associated with behavioral patterns, and the importance of considering nonmendelizing genetic influences when discerning the panorama of genetic influences on behavior.
我们评估了行为遗传学研究范式中的11个关键表观遗传学概念对于推动发展性心理病理学领域发展的实用性。文中呈现了关键假设、实证例子以及解读结果时的注意事项。我们强调在经典双生子和家系研究中纳入维度变量（如气质特质）和分类变量（如诊断）、环境测量、直接行为评估以及多个理论相关研究时机的实用性。我们突出了用于识别与行为模式相关的特定染色体区域的当代技术，以及在辨别遗传对行为的影响全景时考虑非孟德尔遗传影响的重要性。
