4-氨基吡啶和3,4-二氨基吡啶对豚鼠离体回肠的作用。

Effect of 4-aminopyridine and 3,4-diaminopyridine on guinea-pig isolated ileum.

Velasco A, Maroto M, Dueñas A, Carvajal A, Fernández de la Gándara F, Nieto A

Department of Pharmacology, Faculty of Medicine, Valladolld, Spain.

J Auton Pharmacol. 1997 Feb;17(1):53-7. doi: 10.1046/j.1365-2680.1997.00441.x.

Abstract

4-Aminopyridine and 3,4-diaminopyridine produced concentration-dependent contraction on guinea-pig isolated ileum incubated in Tyrode solution. The EC30 values were 1.14 x 10(-4) and 1.39 x 10(-4) M, respectively. 2. Calcium channel blockers such as verapamil, diltiazem, nifedipine, flunarizine, and lanthanum chloride antagonized the contracting effect induced by 4-aminopyridine and 3,4-diaminopyridine in guinea-pig isolated ileum. 3. Diazoxide and atropine sulphate behaved similarly as antagonists of the contracting effect induced by 4-aminopyridine and 3,4-diaminopyridine in guinea-pig isolated ileum. 4. It is concluded that the aminopyridines exert their effects through the release of acetylcholine from parasympathetic nerve terminals.

摘要

4-氨基吡啶和3,4-二氨基吡啶对置于台氏液中孵育的豚鼠离体回肠产生浓度依赖性收缩。其EC30值分别为1.14×10⁻⁴和1.39×10⁻⁴M。2. 钙通道阻滞剂如维拉帕米、地尔硫䓬、硝苯地平、氟桂利嗪和氯化镧可拮抗4-氨基吡啶和3,4-二氨基吡啶对豚鼠离体回肠的收缩作用。3. 二氮嗪和硫酸阿托品作为4-氨基吡啶和3,4-二氨基吡啶对豚鼠离体回肠收缩作用的拮抗剂，表现相似。4. 得出的结论是，氨基吡啶类药物通过副交感神经末梢释放乙酰胆碱发挥作用。