Ingenito A J
Agents Actions. 1985 Dec;17(2):113-20. doi: 10.1007/BF01966578.
The molar concentrations of verapamil, diltiazem, nifedipine, tripelennamine and atropine necessary to block histamine, acetylcholine (ACH) and ovalbumin-induced contractions of the isolated guinea pig ileum were compared. The calcium blockers inhibited ovalbumin contractions in previously sensitized ilea at lower concentrations than those required to block the phasic component of histamine and ACH contractions. These compounds were, however, more active in blocking the tonic phase of histamine and ACH concentrations than ovalbumin contractions. Tripelennamine was almost as active against ovalbumin contractions as it was against histamine concentrations, while atropine was inactive against ovalbumin. The results are interpreted as being supportive of continued efforts to develop calcium channel antagonists which selectively block the smooth muscle effects of inflammatory mediators.
比较了维拉帕米、地尔硫䓬、硝苯地平、曲吡那敏和阿托品阻断组胺、乙酰胆碱（ACH）和卵清蛋白诱导的离体豚鼠回肠收缩所需的摩尔浓度。钙通道阻滞剂在致敏回肠中抑制卵清蛋白收缩所需的浓度低于阻断组胺和ACH收缩的相性成分所需的浓度。然而，这些化合物在阻断组胺和ACH收缩的紧张相方面比阻断卵清蛋白收缩更有效。曲吡那敏对卵清蛋白收缩的作用几乎与对组胺收缩的作用相同，而阿托品对卵清蛋白收缩无作用。这些结果被解释为支持继续努力开发选择性阻断炎症介质平滑肌效应的钙通道拮抗剂。
