Mastrobattista J M
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Texas Health Science Center at Houston 77030, USA.
Semin Perinatol. 1997 Apr;21(2):124-34. doi: 10.1016/s0146-0005(97)80055-9.
Angiotensin converting enzyme (ACE) inhibitors are excellent antihypertensive agents and are becoming widely used as first-line therapy for chronic hypertension in women of reproductive age owing to their efficacy and few side effects. Reports of adverse fetal and neonatal effects from the use of ACE inhibitors in pregnancy in both animal and human studies prompted recommendations against their use in human pregnancy by several authors. This review discusses the mechanism of action of ACE inhibitors and the use of ACE inhibitors in pregnancy both in experimental animals and use in human pregnancy. ACE inhibitors used during pregnancy may have untoward effects on the fetus. Based on reports in the literature, one should avoid starting ACE inhibitors during pregnancy and discontinue them in current users if at all possible.
血管紧张素转换酶（ACE）抑制剂是优秀的抗高血压药物，由于其疗效好且副作用少，正被广泛用作育龄女性慢性高血压的一线治疗药物。动物和人体研究中关于孕期使用ACE抑制剂对胎儿和新生儿产生不良影响的报告促使多位作者建议不要在人类孕期使用此类药物。本综述讨论了ACE抑制剂的作用机制以及其在实验动物孕期和人类孕期的使用情况。孕期使用ACE抑制剂可能会对胎儿产生不良影响。根据文献报道，应避免在孕期开始使用ACE抑制剂，并且如果可能的话，应让正在使用的患者停药。
