Magnusson G, Boberg M, Cederblad G, Meurling S
Department of Paediatric Surgery, University Hospital, Uppsala, Sweden.
Acta Paediatr. 1997 Jun;86(6):638-44. doi: 10.1111/j.1651-2227.1997.tb08948.x.
This study was undertaken to compare Intralipid with a new fat emulsion containing gamma-linolenic acid and carnitine, named Pediatric Fat Emulsion 4501, in neonates with regard to lipid and carnitine metabolism over a short period of total parenteral nutrition. There were 10 neonates in each group and they tolerated the total parenteral nutrition well. In spite of the gamma-linolenic acid supplementation in the new emulsion, arachidonic acid decreased significantly in plasma lipid esters and adipose tissue in both groups after 5 d of treatment. Also, there was a decrease in plasma docosahexaenoic acid which was more pronounced in the treatment group. The relative percentage values of linoleic and linolenic acids in adipose tissue were increased, indicating that newborns have a rapid accretion of fatty acids. Plasma-triglycerides were effectively cleared during the periods without fat infusion. In the group that received Pediatric Fat Emulsion 4501 the means of both free and total plasma carnitine concentrations increased significantly, whereas they tended to decrease in the Intralipid group.
本研究旨在比较在短期全肠外营养期间，脂质乳剂与一种含有γ-亚麻酸和肉碱的新型脂肪乳剂（名为小儿脂肪乳剂4501）在新生儿脂质和肉碱代谢方面的差异。每组有10名新生儿，他们对全肠外营养耐受良好。尽管新型乳剂中添加了γ-亚麻酸，但治疗5天后，两组血浆脂质酯和脂肪组织中的花生四烯酸均显著下降。此外，血浆二十二碳六烯酸也有所下降，在治疗组中更为明显。脂肪组织中亚油酸和亚麻酸的相对百分比值增加，表明新生儿脂肪酸快速蓄积。在无脂肪输注期间，血浆甘油三酯有效清除。在接受小儿脂肪乳剂4501的组中，游离血浆肉碱和总血浆肉碱浓度均值均显著增加，而在脂质乳剂组中则呈下降趋势。
