Kenny G N
University Department of Anaesthesia, Glasgow Royal Infirmary, UK.
Eur J Anaesthesiol Suppl. 1997 May;15:29-31. doi: 10.1097/00003643-199705001-00006.
Propofol has a favourable pharmacokinetic profile for total intravenous anaesthesia and several manual infusion schemes have been proposed to maintain a constant blood concentration during anaesthesia. However, such schemes cannot respond predictably to changing surgical and anaesthetic requirements. A pharmacokinetic model for propofol has been incorporated into a target-controlled infusion system. This allows the desired target blood concentration appropriate for any individual patient and level of surgical stimulation to be achieved and maintained at any time. There is no single blood concentration of an anaesthetic agent which will result in satisfactory anaesthesia for all patients and all surgical conditions. It is necessary to titrate the target concentration against each patient's clinical response. Target-controlled systems provide the best estimate of the blood concentration at any time and permit the required target concentration to be achieved as accurately and as rapidly as possible.
丙泊酚具有适用于全静脉麻醉的良好药代动力学特性，并且已经提出了几种手动输注方案以在麻醉期间维持恒定的血药浓度。然而，这些方案无法对不断变化的手术和麻醉需求做出可预测的反应。丙泊酚的药代动力学模型已被纳入靶控输注系统。这使得能够随时实现并维持适合任何个体患者和手术刺激水平的所需靶血药浓度。没有单一的麻醉药血药浓度能使所有患者在所有手术情况下都获得满意的麻醉效果。有必要根据每个患者的临床反应来滴定靶浓度。靶控系统可随时提供对血药浓度的最佳估计，并允许尽可能准确、快速地达到所需的靶浓度。
