Beths T, Glen J B, Reid J, Monteiro A M, Nolan A M
Zeneca Pharmaceuticals, Macclesfield, Cheshire.
Vet Rec. 2001 Feb 17;148(7):198-203. doi: 10.1136/vr.148.7.198.
The performance of a modified target-controlled infusion system was investigated in 16 dogs undergoing routine dental work, by comparing the predicted concentrations of propofol in venous blood samples with direct measurements; the optimum targets for the induction and maintenance of anaesthesia were also identified. The performance of a target-controlled infusion system is considered clinically acceptable when the median prediction error, a measure of bias, is not greater than +/-10 to 20 per cent, and the median absolute performance error, a measure of the accuracy, is not greater than 20 to 30 per cent. The results fell within these limits indicating that the system performed adequately. The optimal induction target was 3 microg/ml, and anaesthesia of adequate depth and satisfactory quality was achieved with maintenance targets of between 2.5 and 4.7 microg/ml propofol. The system was easy to use and the quality of anaesthesia was adequate for dental work.
通过比较静脉血样本中丙泊酚的预测浓度与直接测量值，研究了一种改良的靶控输注系统在16只接受常规牙科治疗的犬中的性能；还确定了麻醉诱导和维持的最佳目标。当中位预测误差（一种偏差度量）不大于±10%至20%，且中位绝对性能误差（一种准确度度量）不大于20%至30%时，靶控输注系统的性能在临床上被认为是可接受的。结果在这些范围内，表明该系统运行良好。最佳诱导目标为3微克/毫升，通过维持丙泊酚浓度在2.5至4.7微克/毫升之间，实现了深度足够且质量令人满意的麻醉。该系统易于使用，麻醉质量足以满足牙科治疗的需要。
