Schuckit M A, Tipp J E, Smith T L, Wiesbeck G A, Kalmijn J
Department of Psychiatry (116A), Veterans Affairs Medical Center, University of California, San Diego 92161-2002, USA.
J Stud Alcohol. 1997 Jul;58(4):397-404. doi: 10.15288/jsa.1997.58.397.
The level of intensity of response to a drug is likely to influence the future pattern of intake of the substance. This article evaluates a simple Self-Rating of the Effects (SRE) of alcohol form, and reports the relationship between a person's estimate of the amounts of alcohol usually required for four possible effects during three different time frames and his subjective feelings reported during an alcohol challenge.
SRE forms and results of a challenge with 0.9 ml/kg (0.72 g/kg) of ethanol were available for 18 to 29 year old drinking, but not alcohol dependent, men (N = 98). A subset of 40 subjects completed a second SRE form approximately 1 year later.
The correlation between the two SRE administration was .82 (p < .0001), and the results on the SRE were internally consistent, with a higher number of drinks associated with more intense alcohol effects. Focusing on the subjective feelings reported at the 60-minute timepoint during the alcohol challenge, 11 of the 12 alcohol effect categories on the SRE correlated in the predicted direction, including eight that were statistically significant. Evaluating all seven timepoints during the drinking experiment, the average number of drinks on the SRE correlated significantly with the Subjective High Assessment Scale (SHAS) total score at all but the final timepoint. Sons of alcoholics and controls demonstrated similar levels of correlation between SRE and alcohol challenge results. Finally, the SRE correctly identified 79% of the individuals whose levels of response to alcohol fell into the lowest third of intensity during the alcohol challenge, and it correctly classified 60% to 67% of the alcohol challenge subjects who did not fall into that low response category.
The SRE is a simple and reliable measure of a person's estimate of the number of drinks required to achieve a response. The form might be helpful in educating people about the intensity of their response to alcohol and might be useful as a point of discussion in curricula focusing on genetic aspects of alcoholism. When alcohol challenges are not possible in a research protocol, the SRE might help identify a less heterogeneous subgroup of individuals at high risk for alcoholism who have a common mechanism increasing their vulnerability.
对药物的反应强度水平可能会影响该物质未来的摄入模式。本文评估了一种简单的酒精效应自评（SRE）形式，并报告了一个人在三个不同时间框架内对四种可能效应通常所需酒精量的估计与他在酒精激发试验期间报告的主观感受之间的关系。
有18至29岁饮酒但非酒精依赖男性（N = 98）的SRE表格以及0.9 ml/kg（0.72 g/kg）乙醇激发试验的结果。40名受试者的一个子集在大约1年后完成了第二份SRE表格。
两次SRE评估之间的相关性为0.82（p <.0001），SRE的结果在内部是一致的，饮酒量越多，酒精效应越强烈。关注酒精激发试验期间60分钟时间点报告的主观感受，SRE上12种酒精效应类别中的11种在预测方向上相关，其中8种具有统计学意义。评估饮酒实验期间的所有七个时间点，除最后一个时间点外，SRE上的平均饮酒量与主观兴奋评估量表（SHAS）总分显著相关。酗酒者的儿子和对照组在SRE与酒精激发试验结果之间表现出相似的相关性水平。最后，SRE正确识别了79%在酒精激发试验期间对酒精反应强度处于最低三分之一的个体，并且它正确分类了60%至67%不属于低反应类别的酒精激发试验受试者。
SRE是一种简单可靠的测量方法，用于衡量一个人对达到某种反应所需饮酒量的估计。该表格可能有助于让人们了解他们对酒精反应的强度，并且可能作为关注酒精中毒遗传方面的课程中的一个讨论点有用。当在研究方案中无法进行酒精激发试验时，SRE可能有助于识别出一组异质性较小的酒精中毒高风险个体，他们有共同的机制增加了易感性。
