Norwegian Institute of Public Health, Oslo 0213, Norway.
National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, Brumunddal 2381, Norway.
Alcohol Alcohol. 2023 Mar 10;58(2):203-208. doi: 10.1093/alcalc/agad002.
A high number of alcohol units required to feel a subjective effect of alcohol predicts future alcohol use disorders (AUDs). The subjective response to alcohol can be measured using the validated retrospective self-rated effects of alcohol (SRE) questionnaire. Few studies have investigated the specific relationship between SRE and blood alcohol concentration (BAC) in an experimental setting.
Twenty healthy young adult male volunteers who had experience with binge drinking, but did not have AUD, filled out the SRE-questionnaire and were served with a fixed amount of alcohol per body weight. BACs were measured throughout a 12-hour period, reaching a maximum BAC of ~0.13%. Median split of SRE-scores was utilized to compare BACs among participants with relatively high effects (low SRE) and relatively low effects (high SRE) of alcohol.
Participants reporting a relatively low SRE-score had a statistically significant higher measured BAC at all time points until alcohol was eliminated. This was especially pronounced during the first 2 hours after alcohol (P = 0.015) without a significant difference in the alcohol elimination rate being detected.
The study indicates that a self-ated SRE-score is related to BACs after the ingestion of a standardized amount of alcohol per body weight. Reporting a higher number of alcohol units before feeling an effect was related to a lower BAC. As the differences in BAC between relatively high and low self-rated effects appeared rapidly after intake, this could be interpreted as an effect of presystemic metabolism of alcohol.
感受到酒精的主观作用所需的大量酒精单位数可预测未来的酒精使用障碍（AUD）。可以使用经过验证的回顾性自我评估酒精效应（SRE）问卷来测量对酒精的主观反应。在实验环境中，很少有研究调查 SRE 与血液酒精浓度（BAC）之间的特定关系。
20 名有过狂欢饮酒经历但没有 AUD 的健康年轻成年男性志愿者填写了 SRE 问卷，并按体重摄入固定量的酒精。在 12 小时内测量 BAC，达到约 0.13%的最大 BAC。利用 SRE 评分的中位数分割来比较酒精效应相对较高（低 SRE）和相对较低（高 SRE）的参与者之间的 BAC。
报告 SRE 评分相对较低的参与者在所有时间点的测量 BAC 均显著高于其他参与者，直到酒精被消除。这在饮酒后前 2 小时尤为明显（P = 0.015），但未检测到酒精消除率的显著差异。
该研究表明，在摄入标准化体重酒精量后，自我评估的 SRE 评分与 BAC 相关。报告在感到影响之前摄入的酒精单位数越多，BAC 越低。由于相对高和低自我评估效应之间的 BAC 差异在摄入后迅速出现，这可以解释为酒精的预系统代谢作用。
