Brown K E, Wong S, Buu M, Binh T V, Be T V, Young N S
Hematology Branch, National Heart, Lung and Blood Institute, Bethesda, Maryland 20892-1652, USA.
J Infect Dis. 1997 Feb;175(2):450-3. doi: 10.1093/infdis/175.2.450.
GB virus C or hepatitis G virus (GBV-C/HGV), a novel Flavivirus, is detected in 1.5% of US blood donors. The prevalence is higher in multiply transfused patients and in persons with liver disease. Because of the increased incidence of hepatitis in Asia, sera from healthy Vietnamese were tested for the presence of GBV-C/HGV RNA by the reverse transcription polymerase chain reaction. Viral RNA was detected in 5.7% of those tested; 6 of 81 volunteer blood donors had positive samples as did 5 of 97 army recruits and 2 of 50 postpartum women. When the 188-bp product from 6 subjects was sequenced, there was 75%-85% homology at the nucleotide level compared with published sequences, indicating a high degree of genotypic variation, even within a putatively well-conserved region of the viral genome. Viremia with this non-cell-associated novel virus appears to be common among normal persons in Vietnam.
庚型肝炎病毒（GBV-C/HGV）是一种新型黄病毒，在美国1.5%的献血者中可检测到。在多次输血的患者和肝病患者中，其感染率更高。由于亚洲肝炎发病率上升，采用逆转录聚合酶链反应检测了健康越南人的血清中GBV-C/HGV RNA的存在情况。在5.7%的受检者中检测到病毒RNA；81名志愿献血者中有6人样本呈阳性，97名新兵中有5人、50名产后妇女中有2人样本呈阳性。对6名受试者的188bp产物进行测序时，与已发表序列相比，核苷酸水平上有75%-85%的同源性，表明即使在病毒基因组假定保守的区域内，基因型变异程度也很高。这种与细胞无关的新型病毒血症在越南正常人中似乎很常见。
