Lear J T, Neary R H, Jones P, Fitzgerald D A, English J S
Department of Dermatology, North Staffs NHS Trust, Stoke-on-Trent, England.
J R Soc Med. 1997 May;90(5):247-9. doi: 10.1177/014107689709000504.
For reasons that are unclear, patients with dermatitis herpetiformis (DH) have a lower than expected mortality rate from ischaemic heart disease. We have compared risk factors for ischaemic heart disease (lipids, fibrinogen levels, smoking history and social class) in 29 DH patients and 57 controls matched for age and sex. Patients with DH had significantly lower cholesterol, triglycerides, apolipoprotein B and fibrinogen and higher HDL2; they also smoked less and were of higher social class. The mechanisms underlying these observations merit further investigation. Intestinal abnormalities or gluten-free diet may account for differences in lipid fractions, and the immunomodulatory properties of cigarette smoke may protect against the development of DH.
出于尚不清楚的原因，疱疹样皮炎（DH）患者缺血性心脏病的死亡率低于预期。我们比较了29例DH患者和57例年龄及性别匹配的对照组患者的缺血性心脏病风险因素（血脂、纤维蛋白原水平、吸烟史和社会阶层）。DH患者的胆固醇、甘油三酯、载脂蛋白B和纤维蛋白原显著降低，而高密度脂蛋白2（HDL2）较高；他们吸烟较少，社会阶层较高。这些观察结果背后的机制值得进一步研究。肠道异常或无麸质饮食可能是血脂成分差异的原因，而香烟烟雾的免疫调节特性可能对DH的发生起到保护作用。
