Lupas A
Max-Planck-Institut für Biochemie, Martinsried, Germany.
Curr Opin Struct Biol. 1997 Jun;7(3):388-93. doi: 10.1016/s0959-440x(97)80056-5.
The past several years have seen significant advances in our ability to recognize coiled coils from protein sequences and model their structures. New methods include a detection program based on pairwise residue correlations, a program that distinguishes two-stranded from three-stranded coiled coils and a routine for modelling the coordinates of the core residues in coiled coils. Several widely noted predictions, among them those for heterotrimeric G proteins and for cartilage oligomeric matrix protein, have been confirmed by crystal structures, and several new predictions have been made, including a model for the still hypothetical right-handed coiled coil.
在过去几年中，我们从蛋白质序列识别卷曲螺旋并对其结构进行建模的能力取得了重大进展。新方法包括基于成对残基相关性的检测程序、区分双链和三链卷曲螺旋的程序以及对卷曲螺旋核心残基坐标进行建模的例程。一些广受关注的预测，包括对异源三聚体G蛋白和软骨寡聚基质蛋白的预测，已被晶体结构所证实，并且还做出了一些新的预测，包括对仍属假设的右手卷曲螺旋的模型。
