Hirunuma R, Endo K, Yanaga M, Enomoto S, Ambe S, Tanaka A, Tozawa M, Ambe F
Showa College of Pharmaceutical Sciences, Tokyo, Japan.
Appl Radiat Isot. 1997 Jun;48(6):727-33. doi: 10.1016/s0969-8043(96)00316-8.
The uptake by, and distribution and retention of radioactive isotopes in various organs of Wistar rats were examined using the multitracer technique. A hydrocholoric acid solution (pH 3) of a carrier-free radioactive multitracer was prepared from gold foil irradiated with a 14N beam of 135 MeV nucleon. The solution was administered orally to 12 7-week-old male rats. Urine and faeces were collected and each group of three rats was killed at 1, 2, 3 or 6 days after administration. The percentage of administered dose of the 17 elements, Mn, Co, Zn, As, Rb, Sr, Y, Eu, Gd, Er, Tm, Yb, Lu, W, Re, Ir and Pt in the organs blood and excreta were determined using gamma-ray spectrometry. Each element revealed its characteristic distribution among the different organs, including the blood. These results are discussed and compared with those of single-tracer experiments, and the advantages of the multitracer technique are presented.
采用多示踪技术研究了放射性同位素在Wistar大鼠各器官中的摄取、分布和滞留情况。用能量为135MeV核子的14N束照射金箔，制备了无载体放射性多示踪剂的盐酸溶液（pH 3）。将该溶液口服给予12只7周龄雄性大鼠。收集尿液和粪便，并在给药后1、2、3或6天处死每组3只大鼠。使用γ射线光谱法测定了17种元素（锰、钴、锌、砷、铷、锶、钇、铕、钆、铒、铥、镱、镥、钨、铼、铱和铂）在器官、血液和排泄物中给药剂量的百分比。每种元素在包括血液在内的不同器官中都显示出其特征性分布。对这些结果进行了讨论，并与单示踪实验的结果进行了比较，同时介绍了多示踪技术的优点。
