氨酰化反应的结构与功能考量
Structural and functional considerations of the aminoacylation reaction.
作者信息
Arnez J G, Moras D
机构信息
Laboratoire de Biologie Structurale, Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, Illkirch, France.
出版信息
Trends Biochem Sci. 1997 Jun;22(6):211-6. doi: 10.1016/s0968-0004(97)01052-9.
PMID:9204708
Abstract
Aminoacyl-tRNA synthetases (aaRS) bind their substrates-ATP, amino acids and tRNA- and stabilize putative transition states in the aminoacylation reaction. Here, we discuss the common and distinguishing structural and functional themes of the 20 known aaRS, which can be divided into two main classes (I and II) and into further subgroups on this basis.
摘要
氨酰-tRNA合成酶（aaRS）结合其底物——ATP、氨基酸和tRNA——并在氨酰化反应中稳定假定的过渡态。在此，我们讨论20种已知氨酰-tRNA合成酶的共同及独特的结构和功能特点，这些酶可分为两大类（I类和II类），并在此基础上进一步细分亚组。
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