Taylor A, Manatunga A, Morton K, Reese L, Prato F S, Greenberg E, Folks R, Kemp B J, Jones M E, Corrigan P E, Galt J, Eshima L
Department of Radiology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Radiology. 1997 Jul;204(1):47-54. doi: 10.1148/radiology.204.1.9205222.
To evaluate an improved camera-based method for calculating the clearance of technetium-99m mercaptoacetyltriglycine (MAG3) in a multicenter trial.
Tc-99m MAG3 scintigraphy was performed in 49 patients at three sites in the United States and Canada. The percentage of the injected dose of Tc-99m MAG3 in the kidney at 1-2, 1.0-2.5, and 2-3 minutes after injection was correlated with the plasma-based Tc-99m MAG3 clearances. The data were combined with the results obtained in 20 additional patients in a previously published pilot study.
Regression models correlating the plasma-based Tc-99m MAG3 clearance with the percentage uptake in the kidney for each time interval were developed; there was no statistically significant difference among sites in the regression equations. Correction for body surface area statistically significantly (P < .005) improved the correlation coefficient for each time interval. For the 1.0-2.5-minute interval, the body surface area-corrected correlation coefficient for the four combined sites was .87, and it improved to .93 when one outlier was omitted from the analysis. Similar results were obtained with the other time intervals. Independent processing by two observers showed no clinically important differences in the percentage dose in the kidney or in relative function.
An improved camera-based method to calculate the clearance of Tc-99m MAG3 was validated in a multicenter trial.
在一项多中心试验中评估一种改进的基于相机的方法，用于计算锝-99m 巯基乙酰三甘氨酸（MAG3）的清除率。
在美国和加拿大的三个地点，对 49 名患者进行了 Tc-99m MAG3 闪烁显像。注射后 1 - 2 分钟、1.0 - 2.5 分钟和 2 - 3 分钟时，肾脏中 Tc-99m MAG3 注射剂量的百分比与基于血浆的 Tc-99m MAG3 清除率相关。这些数据与之前发表的一项初步研究中另外 20 名患者的结果相结合。
建立了将基于血浆的 Tc-99m MAG3 清除率与每个时间间隔肾脏摄取百分比相关的回归模型；各地点的回归方程之间无统计学显著差异。对体表面积进行校正后，每个时间间隔的相关系数在统计学上有显著改善（P <.005）。对于 1.0 - 2.5 分钟的时间间隔，四个合并地点经体表面积校正后的相关系数为 0.87，当从分析中剔除一个异常值时，相关系数提高到 0.93。其他时间间隔也得到了类似结果。两名观察者的独立处理显示，肾脏中剂量百分比或相对功能方面无临床重要差异。
一种改进的基于相机的计算 Tc-99m MAG3 清除率的方法在一项多中心试验中得到验证。
