Prost R, Haughton V, Li S J
Biophysics Research Institute, Department of Radiology, Medical College of Wisconsin, Milwaukee 53226-0509, USA.
Radiology. 1997 Jul;204(1):235-8. doi: 10.1148/radiology.204.1.9205253.
To investigate the feasibility of obtaining clinically useful magnetic resonance (MR) spectra at 0.5 T in cerebral lesions.
Single-voxel localized proton MR spectroscopy was performed at 0.5 T in 18 patients (aged 16-73 years) suspected of having cerebral lesions on MR images who subsequently underwent craniotomy and biopsy and in eight volunteers (aged 21-50 years). The metabolite resonances in the MR spectra were stratified according to the histologic diagnosis. MR spectra demonstrated resonances for choline-containing compounds (Cho), creatine and phosphocreatine, glutamine and glutamate, N-acetylaspartate (NAA), myo-inositol, and lactate.
In 14 of 15 patients with cerebral tumors, the Cho-NAA ratio was increased and was greater than 1. In three patients with nonneoplastic cerebral lesions, the ratio did not exceed 1. In healthy control subjects, the average ratio was 0.54.
H-1 MR spectroscopy at 0.5 T provides clinically useful information in patients with cerebral lesions.
探讨在0.5T磁场下获取脑病变临床可用磁共振（MR）波谱的可行性。
对18例（年龄16 - 73岁）磁共振成像怀疑有脑病变且随后接受开颅手术和活检的患者以及8名志愿者（年龄21 - 50岁）在0.5T磁场下进行单体素质子磁共振波谱分析。根据组织学诊断对磁共振波谱中的代谢物共振进行分层。磁共振波谱显示了含胆碱化合物（Cho）、肌酸和磷酸肌酸、谷氨酰胺和谷氨酸、N - 乙酰天门冬氨酸（NAA）、肌醇和乳酸的共振峰。
15例脑肿瘤患者中有14例的Cho - NAA比值升高且大于1。3例非肿瘤性脑病变患者的该比值未超过1。健康对照者的平均比值为0.54。
0.5T磁场下的氢质子磁共振波谱可为脑病变患者提供临床有用信息。
