Nyirjesy P, Nixon J M, Jordan C A, Buckley H R
Department of Obstetrics, Gynecology, and Reproductive Sciences, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
Obstet Gynecol. 1994 Oct;84(4 Pt 2):710-1.
In treating women with chronic fungal infections, it is important to know which organism is responsible for the infection. In the past, organisms thought to cause vaginitis and vulvitis could all be cultured on modified Sabouraud agar.
We describe a case of a woman whose chronic fungal vulvar folliculitis masqueraded as squamous epithelial hyperplasia. The 46-year-old woman, taking immunosuppressive therapy for rheumatoid arthritis, was referred with an 8-month history of vulvar vesicles, itching, and burning. Her examination revealed a vulvar folliculitis. When fungal cultures were initially negative, a vulvar biopsy revealed a squamous epithelial hyperplasia. However, a fungal culture covered with sterile olive oil eventually grew Malassezia furfur, a yeast with peculiar growth requirements. She was cured with a 2-week course of fluconazole.
Malassezia furfur, an organism rarely described in the vaginitis literature, can cause vulvar folliculitis in a patient on immunosuppressive therapy.
在治疗患有慢性真菌感染的女性时，了解是哪种病原体导致感染非常重要。过去，人们认为导致阴道炎和外阴炎的病原体都可以在改良的沙氏琼脂培养基上培养。
我们描述了一例慢性真菌性外阴毛囊炎伪装成鳞状上皮增生的病例。这位46岁的女性因类风湿关节炎接受免疫抑制治疗，因有8个月的外阴水疱、瘙痒和灼痛病史前来就诊。检查发现她患有外阴毛囊炎。最初真菌培养结果为阴性，外阴活检显示为鳞状上皮增生。然而，最终在覆盖有无菌橄榄油的真菌培养物中培养出了糠秕马拉色菌，这是一种生长要求特殊的酵母菌。她接受了为期2周的氟康唑治疗后痊愈。
糠秕马拉色菌在阴道炎文献中很少被描述，它可在接受免疫抑制治疗的患者中引起外阴毛囊炎。
