[人正常及白内障晶状体上皮细胞中环磷酸腺苷及钙-钙调蛋白的研究]
[A study on cAMP and Ca-CaM of the epithelium in human normal and cataractous lenses].
作者信息
Liu X, Fang Q, Yan M
机构信息
Department of Ophthalmology, General Naval Hospital, Beijing.
出版信息
Zhonghua Yan Ke Za Zhi. 1996 Mar;32(2):107-9.
OBJECTIVE
The study was designed to study the relationship between calcium-calmodulin (Ca-CaM) and cyclic adenosine monophosphate (cAMP) systems and their possible cataractogenic effects.
METHODS
We measured cAMP, Ca and Ca-CaM in the epithelium of human normal and cataractous lenses by enzymic and radioimmunoassay methods.
RESULTS
The levels of Ca-CaM in the epithelium of senile cataractous lens were higher, while of cAMP were lower than that in the normal lens.
CONCLUSION
The results imply that the low level of cAMP might cause the high level of calcium in the lens which is possibly a cataractogenic factor. The dangerous role of calcium is amplified by the elevation of Ca-CaM.
目的
本研究旨在探讨钙调蛋白（Ca-CaM）与环磷酸腺苷（cAMP）系统之间的关系及其可能的致白内障作用。
方法
我们采用酶法和放射免疫分析法检测了正常及白内障患者晶状体上皮细胞中的cAMP、Ca及Ca-CaM水平。
结果
老年性白内障晶状体上皮细胞中Ca-CaM水平较高，而cAMP水平低于正常晶状体。
结论
结果表明，cAMP水平降低可能导致晶状体中钙水平升高，这可能是一个致白内障因素。Ca-CaM升高放大了钙的危险作用。
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