采用大气压化学电离质谱检测的超临界流体色谱法分析大麻的初步研究。

A preliminary study of the analysis of Cannabis by supercritical fluid chromatography with atmospheric pressure chemical ionisation mass spectroscopic detection.

作者信息

Bäckström B, Cole M D, Carrott M J, Jones D C, Davidson G, Coleman K

机构信息

Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, United Kingdom.

出版信息

Sci Justice. 1997 Apr-Jun;37(2):91-7. doi: 10.1016/S1355-0306(97)72153-1.

DOI:10.1016/S1355-0306(97)72153-1

PMID:9206314

Abstract

A rapid method is described for the analysis of Cannabis products by supercritical fluid chromatography (SFC) coupled to atmospheric pressure chemical ionization-mass spectroscopic (APCI-MS) detection. The method had a shorter analysis time than GC-MS methods, without the need for derivatization prior to analysis. It was also faster than HPLC methods, with better resolution and definitive identification. Linearity of detector response to cannabidiol, delta 8-tetrahydrocannabinol, delta 9-tetrahydrocannabinol and cannabinol was established, the detection limits for mass on column being 0.55 ng, 1.20 ng, 0.69 ng and 2.10 ng respectively. The technique offers a means by which Cannabis products can be definitively identified in a single chromatographic run. Application to casework samples is described.

摘要

描述了一种通过超临界流体色谱（SFC）与大气压化学电离质谱（APCI-MS）检测联用分析大麻产品的快速方法。该方法的分析时间比气相色谱-质谱（GC-MS）方法短，分析前无需衍生化。它也比高效液相色谱（HPLC）方法更快，具有更好的分辨率和明确的鉴定结果。建立了检测器对大麻二酚、δ8-四氢大麻酚、δ9-四氢大麻酚和大麻酚的响应线性，柱上质量检测限分别为0.55 ng、1.20 ng、0.69 ng和2.10 ng。该技术提供了一种在单次色谱运行中就能明确鉴定大麻产品的方法。还描述了该方法在实际案件样本中的应用。