Boĭko S S, Zherdev V P, Dvorianinov A A, Gudasheva T A, Ostrovskaia R U, Voronina T A, Rozantsev G G, Seredenin S B
Eksp Klin Farmakol. 1997 Mar-Apr;60(2):53-5.
The pharmacokinetics of a new nootropic dipeptide analog of piracetam-N-phenylacetyl-L-prolylglycine (GWS-111) and its main metabolites were studied in rats by means of high performance liquid chromatography and gas-liquid chromatography. The compound under study showed a greater resistance to an enzymatic effect than natural neuropeptides. In addition to an unchanged compound three of its metabolites were found in the blood plasma of the rats. One of them, cyclo-Pro-Gly was an active metabolite of GWS-111.
通过高效液相色谱法和气液色谱法，在大鼠体内研究了一种新型促智二肽类似物——吡拉西坦-N-苯乙酰-L-脯氨酰甘氨酸（GWS-111）及其主要代谢产物的药代动力学。与天然神经肽相比，所研究的化合物对酶作用表现出更大的抗性。除了未发生变化的化合物外，在大鼠血浆中还发现了其三种代谢产物。其中一种，环脯氨酰甘氨酸是GWS-111的活性代谢产物。
