Inozemtsev A N, Trofimov S S, Borlikova G G, Firova F A, Pragina L L, Gudasheva T A, Ostrovskaia R U, Tushmalova N A, Voronina T A
Lomonosov Moscow State University, Russia.
Eksp Klin Farmakol. 1998 May-Jun;61(3):10-2.
The authors studied the effect of a new nootropic agent with anxiolytic properties GVS-111 (ethyl ether N-phenylacetyl-L-prolylglycine) on formation of the avoidance reaction (AR) in rats and its functional disorders which were induced by two methods. In one case the stereotype of the relations between the stimulus, reaction and its consequence which developed during the experiment were urgently disturbed: the change of the animal to the other half of the chamber in response to a conditioned stimulus did not lead to its cutting off and prevention of the electropain stimulation for three successive combinations (AR error). In another case the spatial stereotype of the experiment was altered by changing the place of the opening through which the animal avoided the stimulus (spatial remodeling). Intraperitoneal injection of GVS-111 (0.1 mg/kg/day) improved the learning, but the effect differed from experiment to experiment. Along with this, the dipeptide prevented AR disturbance during the error and quickened restoration of the habit in spatial remodeling. It was shown earlier that AR disorders during an error are prevented by anxiolytics and nootropic agents but during spatial remodeling only by nootropic agents. It may be assumed that the positive effect of GSV-111 on AR in functional disorders is due to its nootropic effect.
作者研究了一种具有抗焦虑特性的新型促智药GVS - 111（N - 苯基乙酰基 - L - 脯氨酰甘氨酸乙醚）对大鼠回避反应（AR）形成及其由两种方法诱导的功能障碍的影响。在一种情况下，实验过程中形成的刺激、反应及其后果之间关系的刻板模式被紧急扰乱：动物对条件刺激做出反应而转移到实验箱另一半时，连续三次组合都没有导致切断和防止电疼痛刺激（AR错误）。在另一种情况下，通过改变动物回避刺激的开口位置来改变实验的空间刻板模式（空间重塑）。腹腔注射GVS - 111（0.1毫克/千克/天）改善了学习，但效果因实验而异。与此同时，该二肽在出现错误时防止了AR紊乱，并加速了空间重塑中习惯的恢复。之前的研究表明，抗焦虑药和促智药可防止出现错误时的AR紊乱，但在空间重塑中只有促智药能起到这种作用。可以推测，GSV - 111对功能障碍中AR的积极作用归因于其促智作用。
