Boĭko S S, Zherdev V P, Gudasheva T A, Vasilevich N I, Ostrovskaia R U, Voronina T A, Rozantsev G G
Eksp Klin Farmakol. 1996 Mar-Apr;59(2):38-40.
HPLC method has been developed for pharmacokinetic study of nootropic peptide analog of pyracetam GVS-111 and its main metabolites. In the model experiments on rats the enzymes of blood plasma were shown to metabolize GVS-111 during 1-h incubation with the formation of metabolite, phenylacetylproline. This suggests that in vivo experiments these blood plasma enzymes will also be actively involved in the metabolism of the compound tested. The liver tissue enzymes metabolized GVS-111 much slower.
已开发出高效液相色谱法用于研究吡拉西坦的促智肽类似物GVS-111及其主要代谢产物的药代动力学。在大鼠模型实验中，血浆酶在与GVS-111孵育1小时的过程中会将其代谢，生成代谢产物苯乙酰脯氨酸。这表明在体内实验中，这些血浆酶也会积极参与受试化合物的代谢。肝组织酶对GVS-111的代谢则要慢得多。
