Piskun R P, Pentiuk A A, Serkova V K, Polesia T L, Savitskaia E A
Eksp Klin Farmakol. 1997 Mar-Apr;60(2):78-85.
The main trends of contemporary pharmacology of hypolipidemic and hypocholesterolemic agents were analysed. A list of drugs capable of correcting lipid metabolism disorders is given: cholesterol absorption inhibitors, stimulators of bile acid synthesis, inhibitors of cholesterol synthesis, analogs of fibroic acid and other inhibitors and correctors of hypertriglyceridemias, stimulators of reverse cholesterol transport and synthesis of high-density lipoproteins, etc. The latest theoretical and experimental elaborations of gene therapy of dyslipoproteinemias in atherosclerosis are discussed.
分析了当代降血脂和降胆固醇药物药理学的主要趋势。列出了能够纠正脂质代谢紊乱的药物清单：胆固醇吸收抑制剂、胆汁酸合成刺激剂、胆固醇合成抑制剂、纤维酸类似物以及其他高甘油三酯血症的抑制剂和校正剂、胆固醇逆向转运和高密度脂蛋白合成刺激剂等。讨论了动脉粥样硬化中脂蛋白异常血症基因治疗的最新理论和实验进展。
