Wenkel H, Michelson G
Aúgenklinik mit Poliklinik, Universität Erlangen-Nürnberg.
Klin Monbl Augenheilkd. 1997 Jan;210(1):48-52. doi: 10.1055/s-2008-1035013.
A biopsy of the temporal arteries is still the appropriate method to prove the diagnosis of giant cell arteritis. We evaluated the potential use of high-resolution ultrasound-biomicroscopy in the diagnosis of giant cell arteritis.
In a prospective study we examined 16 patients (8 women and 8 men) with a mean age of 71 years with the clinical suspicion of a giant cell arteritis. Additionally to the clinical examination the temporal arteries were imaged in all patients using the ultrasound-biomicroscopy (Zeiss-Humphrey Instruments). The results were correlated to the histopathologic changes of the temporal arteries excised bilaterally at the same location.
Histopathological evaluation revealed a granulomatous arteritis in 4 out of 16 examined patients. The temporal arteries of these patients also showed characteristic changes using ultrasound biomicroscopy like middle-reflective shadowing of the arterial lumen and a condensation and enlargement of the muscularis media. Ultrasound-biomicroscopy allowed a precise evaluation of the temporal arteries due to a high-resolution sonographic image. The morphological differentiation between a normal and an affected artery was possible. A positive correlation between histopathological and clinical findings was seen in all patients.
In this preliminary study the ultrasound-biomicroscopy seemed to be an appropriate non-invasive tool for the morphological imaging and evaluation of temporal arteries.
颞动脉活检仍是确诊巨细胞动脉炎的适宜方法。我们评估了高分辨率超声生物显微镜在巨细胞动脉炎诊断中的潜在应用价值。
在一项前瞻性研究中，我们对16例（8名女性和8名男性）平均年龄为71岁、临床怀疑患有巨细胞动脉炎的患者进行了检查。除临床检查外，所有患者均使用超声生物显微镜（蔡司 - 汉弗莱仪器）对颞动脉进行成像。将结果与在同一位置双侧切除的颞动脉的组织病理学变化进行关联。
组织病理学评估显示，16例受检患者中有4例存在肉芽肿性动脉炎。这些患者的颞动脉在超声生物显微镜下也显示出特征性变化，如动脉管腔的中等反射性阴影以及中膜的增厚和增宽。由于高分辨率超声图像，超声生物显微镜能够对颞动脉进行精确评估。正常动脉与病变动脉之间的形态学区分是可能的。所有患者的组织病理学和临床结果之间均存在正相关。
在这项初步研究中，超声生物显微镜似乎是一种用于颞动脉形态学成像和评估的合适的非侵入性工具。
