Struthers J E, Mehta S J, Kaye M D, Naylor J L
Am J Dig Dis. 1977 Oct;22(10):861-5. doi: 10.1007/BF01076160.
The relative concentrations of individual nonsulfated bile acids were determined in samples of serum and bile obtained simultaneously from 16 patients with biopsy-proven alcoholic cirrhosis. A highly significant (P less than 0.001) correlation was found between the fasting relative concentrations of each of the three major bile acids (cholic, chenodeoxycholic, and deoxycholic) in serum and bile. This relationship persisted after manipulation of bile acid pools produced by feeding of individual bile acids. We conclude that the relative concentrations of individual nonsulfated bile acids in serum accurately reflect those in bile and that measurement of individual serum bile acids may be used for screening and serial determination purposes. In particular, low levels of biliary deoxycholate can be reliably predicted by serum measurements.
在16例经活检证实为酒精性肝硬化的患者中，同时采集血清和胆汁样本，测定了各非硫酸化胆汁酸的相对浓度。血清和胆汁中三种主要胆汁酸（胆酸、鹅去氧胆酸和脱氧胆酸）各自的空腹相对浓度之间存在高度显著相关性（P小于0.001）。在投喂单个胆汁酸产生胆汁酸池变化后，这种关系依然存在。我们得出结论，血清中各非硫酸化胆汁酸的相对浓度准确反映了胆汁中的浓度，个体血清胆汁酸的测定可用于筛查和连续测定目的。特别是，血清检测能够可靠地预测胆汁中脱氧胆酸盐的低水平。
