肝硬化患者继发性胆汁酸的代谢异常。
Abnormal metabolism of secondary bile acids in patients with cirrhosis.
作者信息
Vlahcevic Z R, Buhac I, Bell C C, Swell L
出版信息
Gut. 1970 May;11(5):420-2. doi: 10.1136/gut.11.5.420.
Abstract
The composition of bile acids in human bile was determined in bile-rich duodenal fluid on four consecutive days in a group of seven patients with cirrhosis and eight control patients with no liver disease. There was a marked reduction of secondary biliary bile acids in cirrhotic patients. Possible mechanisms for these changes are discussed.
摘要
在一组7例肝硬化患者和8例无肝脏疾病的对照患者中，连续4天对富含胆汁的十二指肠液中的人胆汁酸成分进行了测定。肝硬化患者的次级胆汁酸明显减少。讨论了这些变化的可能机制。
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本文引用的文献
1
The effect of oral neomycin on the conversion of cholic acid to deoxycholic in man.口服新霉素对人体中胆酸转化为脱氧胆酸的影响。
Arch Biochem Biophys. 1963 Apr;101:7-13. doi: 10.1016/0003-9861(63)90527-7.
2
3
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.
4
Turnover and nature of fecal bile acids in germfree and infected rats fed cholic acid-24-14C; bile acids and steroids 41.无菌和感染大鼠喂食胆酸-24-¹⁴C后粪便胆汁酸的周转率和性质；胆汁酸与类固醇41
Proc Soc Exp Biol Med. 1957 Mar;94(3):467-71. doi: 10.3181/00379727-94-22981.
5
Metabolism of desoxycholic acid in the rabbit. Bile acids and steroids, 28.兔体内脱氧胆酸的代谢。胆汁酸与类固醇，第28篇。
Acta Physiol Scand. 1955 Oct 27;34(2-3):287-94. doi: 10.1111/j.1748-1716.1955.tb01248.x.
6
Degradation of bile salts by human intestinal bacteria.人类肠道细菌对胆汁盐的降解作用。
Gut. 1968 Feb;9(1):22-7. doi: 10.1136/gut.9.1.22.
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