Bykov V L
Arkh Patol. 1997 Mar-Apr;59(2):71-5.
Oral mucosa contains a system of dendritic antigen-presenting cells which provide its specific immune defence. These cells are found both in mucosal epithelium and lamina propria and possess specific ultrastructural, cytochemical, immunocytochemical and functional properties. Langerhans cells are the most numerous and well-studied population of antigen-presenting cells in oral mucosa. However, epithelium and lamina propria harbour other types of dendritic cells. Dendritic cells trap antigens process them and provide them to lymphocytes; they also influence other mucosal cell types. This review summarizes recent data on distribution, morphologic and functional characteristics of dendritic antigen-presenting cells of the oral mucosa in health and in some pathological conditions. A possible role of these cells in pathogenesis of some diseases is discussed.
口腔黏膜含有一个树突状抗原呈递细胞系统，该系统提供其特异性免疫防御。这些细胞存在于黏膜上皮和固有层中，并具有特定的超微结构、细胞化学、免疫细胞化学和功能特性。朗格汉斯细胞是口腔黏膜中数量最多且研究最充分的抗原呈递细胞群体。然而，上皮和固有层中还存在其他类型的树突状细胞。树突状细胞捕获抗原、处理抗原并将其呈递给淋巴细胞；它们还影响其他黏膜细胞类型。本综述总结了关于健康状态及某些病理状况下口腔黏膜树突状抗原呈递细胞的分布、形态和功能特征的最新数据。讨论了这些细胞在某些疾病发病机制中的可能作用。
