Role of Langerhans cells and other dendritic cells in disease states.

Langerhans cells belong to the dendritic cell lineage and function as potent antigen-presenting cells in the skin epidermis. During the last decade, much has been learned on dendritic cell involvement in the pathogenesis of disease states. This review briefly summarizes our current understanding of the role played by Langerhans cells and other dendritic cells in the pathogenesis of immune-mediated, neoplastic and infectious disorders.