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Comparison of six procedures for the simultaneous determination of antiepileptic drugs.

作者信息

Abraham C V

出版信息

Am J Med Technol. 1977 Oct;43(10):935-8.

PMID:920749
Abstract

A comparison of six gas-chromatographic procedures for the simultaneous analysis of antiepileptic drugs was made. Methylation with 0.2M trimethylanilinium hydroxide was superior to other derivatizing procedures evaluated. The methylated derivatives of phenobarbital, carba-mazepine, primidone, and diphenyl-hydantoin were separated on the chromatogram, and the peaks were sharp and symmetrical. The four drugs gave linear curves to twice their toxic levels.

摘要

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