Abraham C V
Am J Med Technol. 1977 Oct;43(10):935-8.
A comparison of six gas-chromatographic procedures for the simultaneous analysis of antiepileptic drugs was made. Methylation with 0.2M trimethylanilinium hydroxide was superior to other derivatizing procedures evaluated. The methylated derivatives of phenobarbital, carba-mazepine, primidone, and diphenyl-hydantoin were separated on the chromatogram, and the peaks were sharp and symmetrical. The four drugs gave linear curves to twice their toxic levels.