Lipohexin, a new inhibitor of prolyl endopeptidase from Moeszia lindtneri (HKI-0054) and Paecilomyces sp. (HKI-0055; HKI-0096). I. Screening, isolation and structure elucidation.

作者信息

Heinze S, Ritzau M, Ihn W, Hülsmann H, Schlegel B, Dornberger K, Fleck W F, Zerlin M, Christner C, Gräfe U, Küllertz G, Fischer G

机构信息

Hans-Knöll-Institute of Natural Products Research, Jena, Germany.

出版信息

J Antibiot (Tokyo). 1997 May;50(5):379-83. doi: 10.7164/antibiotics.50.379.

Lipohexin was isolated as a novel lipohexapeptide (I) (C39H68N6O9) from three fungal strains, Moeszia lindtneri HKI-0054, Paecilomyces sp. HKI-0055 and Paecilomyces sp. HKI-0096. The structure was elucidated by detailed mass spectrometric and NMR experiments. The proline-containing peptide displays moderate antibacterial activity against Bacillus subtilis ATCC 6633 and inhibits competitively the prolyl endopeptidase from human placenta.