SNA-8073-B, a new isotetracenone antibiotic inhibits prolyl endopeptidase. I. Fermentation, isolation and biological properties. - Suppr | 超能文献

SNA-8073-B, a new isotetracenone antibiotic inhibits prolyl endopeptidase. I. Fermentation, isolation and biological properties.

作者信息

Kimura K, Kanou F, Koshino H, Uramoto M, Yoshihama M

机构信息

Research Institute of Life Science, Snow Brand Milk Products Co., Ltd., Tochigi, Japan.

出版信息

J Antibiot (Tokyo). 1997 Apr;50(4):291-6. doi: 10.7164/antibiotics.50.291.

DOI:10.7164/antibiotics.50.291

Abstract

SNA-8073-B, an inhibitor of prolyl endopeptidase isolated from the broth filtrate of Streptomyces sp. SNA-8073, is a new isotetracenone antibiotic. It was purified by ethyl acetate extraction, silica gel column chromatography and high performance liquid chromatography on ODS column. SNA-8073-B has the molecular formula of C20H16O5 and is a stereoisomer of SNA-8073-A (fujianmycin B, rubiginone A2). SNA-8073-B inhibited prolyl endopeptidase of Flavobacterium non-competitively (IC50 = 8.9 microM) when Z-Gly-Pro-pNA was used as a substrate, but SNA-8073-A did not show any inhibition even at 60 microM.

摘要

相似文献

1

SNA-8073-B, a new isotetracenone antibiotic inhibits prolyl endopeptidase. I. Fermentation, isolation and biological properties.

J Antibiot (Tokyo). 1997 Apr;50(4):291-6. doi: 10.7164/antibiotics.50.291.

2

Propeptin, a new inhibitor of prolyl endopeptidase produced by Microbispora. I. Fermentation, isolation and biological properties.

J Antibiot (Tokyo). 1997 May;50(5):373-8. doi: 10.7164/antibiotics.50.373.

3

Poststatin, a new inhibitor of prolyl endopeptidase, produced by Streptomyces viridochromogenes MH534-30F3. I. Taxonomy, production, isolation, physico-chemical properties and biological activities.

J Antibiot (Tokyo). 1991 Sep;44(9):949-55. doi: 10.7164/antibiotics.44.949.

4

Lipohexin, a new inhibitor of prolyl endopeptidase from Moeszia lindtneri (HKI-0054) and Paecilomyces sp. (HKI-0055; HKI-0096). I. Screening, isolation and structure elucidation.

J Antibiot (Tokyo). 1997 May;50(5):379-83. doi: 10.7164/antibiotics.50.379.

5

Eurystatins A and B, new prolyl endopeptidase inhibitors. I. Taxonomy, production, isolation and biological activities.

J Antibiot (Tokyo). 1992 Oct;45(10):1573-9. doi: 10.7164/antibiotics.45.1573.

6

YM-181741, a novel benz[a]anthraquinone antibiotic with anti-Helicobacter pylori activity from Streptomyces sp.

J Antibiot (Tokyo). 2002 Jan;55(1):30-5. doi: 10.7164/antibiotics.55.30.

7

Propeptin, a new inhibitor of prolyl endopeptidase produced by microbispora II. Determination of chemical structure.

J Antibiot (Tokyo). 2002 Mar;55(3):296-300. doi: 10.7164/antibiotics.55.296.

8

Prolyl endopeptidase inhibitors derived from actinomycetes.

Biosci Biotechnol Biochem. 1997 Oct;61(10):1754-6. doi: 10.1271/bbb.61.1754.

9

Chemical and biological properties of rubiginone, a complex of new antibiotics with vincristine-cytotoxicity potentiating activity.

J Antibiot (Tokyo). 1990 Aug;43(8):967-76. doi: 10.7164/antibiotics.43.967.

10

New biologically active rubiginones from Streptomyces sp.

J Antibiot (Tokyo). 2000 Apr;53(4):329-36. doi: 10.7164/antibiotics.53.329.

引用本文的文献

1

Genome mining of novel rubiginones from Streptomyces sp. CB02414 and characterization of the post-PKS modification steps in rubiginone biosynthesis.

Microb Cell Fact. 2021 Oct 2;20(1):192. doi: 10.1186/s12934-021-01681-5.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。