Marteau P, Vaerman J P, Dehennin J P, Bord S, Brassart D, Pochart P, Desjeux J F, Rambaud J C
INSERM U 290, Hôpital Saint-Lazare, Paris, France.
Gastroenterol Clin Biol. 1997;21(4):293-8.
Link-Amster reported an increase in serum IgA when healthy subjects ingested a fermented dairy product containing Lactobacillus johnsonii La1. We aimed to assess the effects of La1 on the jejunal secretions and serum concentrations of total and specific immunoglobulins and proteins.
Twelve healthy volunteers ingested a fermented milk containing La1 or a control from day 1 till day 28, following a randomised double blind protocol. At days 0 and 28, the jejunum was successively perfused with a control solution and with a La1 suspension. The serum concentrations and jejunal secretions of albumin, orosomucoid, transferrin, alpha 2-macroglobulin, m-IgA, p-IgA, IgG, IgM, secretory component, and specific antibodies against La1 were assessed.
Serum concentrations of IgA slightly increased between d0 and d28 in the group receiving La1 (1.85 +/- 0.64 g/L vs 1.76 +/- 0.76; P = 0.02). The other parameters were not altered.
This study shows that the immunomodulating effects of La1 ingestion in man are not due to modification of jejunal protein permeability.
Link - Amster报道，健康受试者摄入含有约氏乳杆菌La1的发酵乳制品后，血清IgA有所增加。我们旨在评估La1对空肠分泌物以及总免疫球蛋白、特异性免疫球蛋白和蛋白质的血清浓度的影响。
12名健康志愿者按照随机双盲方案，从第1天至第28天摄入含有La1的发酵乳或对照品。在第0天和第28天，空肠先后用对照溶液和La1悬液进行灌注。评估白蛋白、类粘蛋白、转铁蛋白、α2 -巨球蛋白、m - IgA、p - IgA、IgG、IgM、分泌成分以及针对La1的特异性抗体的血清浓度和空肠分泌物。
在接受La1的组中，第0天和第28天之间血清IgA浓度略有增加（1.85±0.64 g/L对1.76±0.76；P = 0.02）。其他参数未改变。
本研究表明，人类摄入La1的免疫调节作用并非由于空肠蛋白质通透性的改变。
