Bental T, Lishner M, Lalkin A, Elis A, Ravid M
Department of Medicine, Meir Hospital, Kfar Sava, Israel.
J Clin Pharmacol. 1997 Jun;37(6):514-9. doi: 10.1002/j.1552-4604.1997.tb04329.x.
The efficacy of a once-daily dose of enalapril was compared with a thrice-daily dose of captopril in an open-label, randomized parallel group study of 27 hypertensive patients. The patients were monitored using conventional measurements of blood pressure and with 24-hour ambulatory blood pressure monitoring at baseline and after 12 weeks of therapy. The end points were 24-hour, daytime, and nighttime mean blood pressure values and the percentage of elevated systolic and diastolic measurements, reflecting the "hypertensive load." Enalapril reduced mean 24-hour systolic blood pressure by 18 mmHg and diastolic blood pressure by 11 mmHg. The comparative values for captopril were 9 mmHg and 2 mmHg, respectively. The mean daytime systolic blood pressure was reduced by 20 mmHg with enalapril versus 7 mmHg with captopril; the diastolic values were lowered by 11 mmHg with enalapril versus 4 mmHg with captopril. The mean nighttime systolic blood pressure was lowered by 16 mmHg with enalapril versus 12 mmHg with captopril; the diastolic values were reduced by 10 mmHg with enalapril and 5 mmHg with captopril. No major side effects were recorded in either group. A single daily 20-mg dose of enalapril, therefore, proved to be equipotent or superior to 75 mg of captopril administered in three divided doses.
在一项针对27名高血压患者的开放标签、随机平行组研究中，对每日一次剂量的依那普利与每日三次剂量的卡托普利的疗效进行了比较。在基线和治疗12周后，使用常规血压测量方法和24小时动态血压监测对患者进行监测。终点指标为24小时、日间和夜间平均血压值，以及反映“高血压负荷”的收缩压和舒张压升高测量值的百分比。依那普利使24小时平均收缩压降低18 mmHg，舒张压降低11 mmHg。卡托普利的相应比较值分别为9 mmHg和2 mmHg。依那普利使日间平均收缩压降低20 mmHg，而卡托普利为7 mmHg；依那普利使舒张压降低11 mmHg，而卡托普利为4 mmHg。依那普利使夜间平均收缩压降低16 mmHg，而卡托普利为12 mmHg；依那普利使舒张压降低10 mmHg，而卡托普利为5 mmHg。两组均未记录到严重副作用。因此，每日一次20 mg剂量的依那普利被证明与分三次服用75 mg卡托普利等效或更优。
