Cheney C L, Mahloch J, Freeny P
Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, Seattle, USA.
Am J Clin Nutr. 1997 Jul;66(1):141-6. doi: 10.1093/ajcn/66.1.141.
It is common for women undergoing treatment for breast cancer to gain weight, although the characteristics of the weight change have not been described. We investigated the changes in abdominal fat accumulation that accompanied the change in weight associated with treatment for breast cancer in longitudinal and cross-sectional clinical studies in 34 women aged 39-73 y with early-stage primary breast cancer. Computerized tomography scans of abdominal subcutaneous and visceral adipose depots, bioelectrical impedance measurements of body fat mass, and measurements of body weight and girth were obtained early in the course of treatment and 6 mo later (longitudinal study; n = 8) or within 12 mo of treatment (cross-sectional study; n = 26). The longitudinal study found that, irrespective of the direction of weight change, seven of eight women gained body fat and lost lean body mass. In the five women who gained weight (median: 3.2 kg) two lost and three gained subcutaneous adipose fat (median: 19%) whereas all gained visceral fat (median: 23%). In the cross-sectional study 19 women gained weight and 7 lost weight or had stable weight since diagnosis. Change in weight was correlated with abdominal subcutaneous adipose fat (r = 0.39; P = 0.06) and hip circumference (r = 0.43; P = 0.03) but not abdominal visceral fat, the ratio of subcutaneous to visceral fat, or the ratio of waist to hip size. In the longitudinal sample, weight gain resulted in a variable response in subcutaneous adipose volumes but a consistent increase in visceral adipose depot. Although these results are preliminary, it appeared that regardless of weight gain or loss women were likely to lose lean body mass and gain fat mass during treatment for breast cancer.
接受乳腺癌治疗的女性体重增加是很常见的，尽管体重变化的特征尚未得到描述。我们在一项纵向和横断面临床研究中，对34名年龄在39 - 73岁的早期原发性乳腺癌女性进行了调查，以研究乳腺癌治疗相关体重变化所伴随的腹部脂肪堆积变化。在治疗过程早期及6个月后（纵向研究；n = 8）或治疗12个月内（横断面研究；n = 26），获取了腹部皮下和内脏脂肪库的计算机断层扫描图像、身体脂肪量的生物电阻抗测量值以及体重和腰围测量值。纵向研究发现，无论体重变化方向如何，8名女性中有7名增加了身体脂肪并减少了瘦体重。在体重增加的5名女性中（中位数：3.2 kg），2名减少了皮下脂肪，3名增加了皮下脂肪（中位数：19%），而所有女性的内脏脂肪均增加（中位数：23%）。在横断面研究中，19名女性自诊断后体重增加，7名体重减轻或体重稳定。体重变化与腹部皮下脂肪（r = 0.39；P = 0.06）和臀围（r = 0.43；P = 0.03）相关，但与腹部内脏脂肪、皮下与内脏脂肪比例或腰臀比无关。在纵向样本中，体重增加导致皮下脂肪量的反应各异，但内脏脂肪库持续增加。尽管这些结果是初步的，但似乎无论体重增加或减少，女性在乳腺癌治疗期间都可能减少瘦体重并增加脂肪量。
