Lloyd G, Howells J, Liddle C, Klineberg P L
Centre for Applied Microbiology and Research, Porton Down, UK.
Anaesth Intensive Care. 1997 Jun;25(3):235-8. doi: 10.1177/0310057X9702500304.
It has been suggested that breathing circuits contaminated with body fluids may provide a route of nosocomial patient-to-patient transmission of the hepatitis C virus. Thus, a number of authorities have recommended the use of breathing circuit filters to minimize such risks. The present study sought to simulate a humidified breathing circuit and evaluate two different designs of breathing circuit filters to determine their efficacy in preventing passage of the hepatitis C virus. A hydrophobic pleated-membrane filter consistently prevented the passage of hepatitis C virus while a large-pore "electret" filter design was ineffective. We conclude that not all filter types are equally suited to preventing the passage of viruses and we therefore consider it essential that, if filters are intended to prevent the passage of named pathogens in a humidified breathing circuit, they should be evaluated in a similar experimental system to that described in order to prove their efficacy.
有人提出，被体液污染的呼吸回路可能提供丙型肝炎病毒在医院内患者间传播的途径。因此，一些权威机构建议使用呼吸回路过滤器以将此类风险降至最低。本研究旨在模拟一个加湿的呼吸回路，并评估两种不同设计的呼吸回路过滤器，以确定它们在防止丙型肝炎病毒通过方面的效果。一种疏水褶膜过滤器始终能防止丙型肝炎病毒通过，而一种大孔径“驻极体”过滤器设计则无效。我们得出结论，并非所有类型的过滤器都同样适合防止病毒通过，因此我们认为至关重要的是，如果过滤器旨在防止特定病原体在加湿的呼吸回路中通过，那么应在与本文所述类似的实验系统中对其进行评估，以证明其有效性。
