Bockman D E, Muller M, Büchler M, Friess H, Beger H G
Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta 30912-2000, USA.
Int J Pancreatol. 1997 Apr;21(2):119-26. doi: 10.1007/BF02822383.
Chronic pancreatitis and restricted pancreatic outflow are accompanied by pathological changes in the ducts, including inflammation and alterations in the microvasculature. These changes and loss of epithelium provide a likely explanation for increased release of serum proteins, immunoglobulins, and lactoferrin into the juice, and the possibility of luminal contents entering the extracellular space and bloodstream.
Enlargement of pancreatic ducts is a well-known phenomenon accompanying chronic pancreatitis and conditions restricting outflow of pancreatic juice. However, the relationship between ductal pathology and concomitant changes in the pancreatic juice is incompletely understood.
Segments of pancreatic ducts removed at surgery from patients with chronic pancreatitis and conditions restricting outflow were studied by light and electron microscopy to assess the pathological changes.
Pathological changes in ducts from patients with chronic pancreatitis include chronic inflammation in the wall, enlarged and numerous capillaries packed with erythrocytes and leukocytes close to the lumen, and loss of epithelium and sometimes basement membrane. Plasma cells provide a source for increased immunoglobulins. Ducts from patients with diseases restricting outflow show significant pathology.
慢性胰腺炎和胰腺流出受限伴有导管的病理变化，包括炎症和微血管改变。这些变化以及上皮细胞的丧失可能解释了血清蛋白、免疫球蛋白和乳铁蛋白向胰液中释放增加，以及管腔内容物进入细胞外空间和血液的可能性。
胰腺导管扩张是伴随慢性胰腺炎和限制胰液流出情况的一种众所周知的现象。然而，导管病理与胰液中伴随变化之间的关系尚未完全了解。
通过光学显微镜和电子显微镜研究从患有慢性胰腺炎和限制流出情况的患者手术中切除的胰腺导管段，以评估病理变化。
慢性胰腺炎患者导管的病理变化包括管壁慢性炎症、靠近管腔的扩大且充满红细胞和白细胞的大量毛细血管，以及上皮细胞丧失，有时还有基底膜丧失。浆细胞是免疫球蛋白增加的来源。患有限制流出疾病患者的导管显示出明显的病理变化。
