Matsuno S, Sasaki Y, Kobari M, Takeda K, Nakamura R, Rahman M M
First Department of Surgery, Tohoku University School of Medicine, Sendai.
Tohoku J Exp Med. 1991 Mar;163(3):199-210. doi: 10.1620/tjem.163.199.
An experimental chronic pancreatitis model was made in five dogs with chronic pancreatic fistula by injection of microspheres into the peripheral pancreatic duct. Sequential changes of pancreatic exocrine and endocrine functions with morphology were studied. Significant decreases in volume bicarbonate output and amylase output were detected in each sample collected separately on secretin and secretin cerulean stimulation. While the viscosity of pancreatic juice was significantly increased with a concomitant increase in hexosamine concentration, chronic pancreatitis was demonstrated morphologically. These results suggest that concentrated pancreatic juice caused by a decrease in volume and an increase in viscosity of pancreatic juice with a concomitant increase in hexosamine concentration brings about the progression of chronic pancreatitis in this experimental model.
通过向五只患有慢性胰瘘的犬的胰腺外周导管注射微球，建立了实验性慢性胰腺炎模型。研究了胰腺外分泌和内分泌功能随形态学的连续变化。在分别用促胰液素和促胰液素-天蓝肽刺激后单独收集的每个样本中，检测到碳酸氢盐分泌量和淀粉酶分泌量显著降低。虽然胰液粘度显著增加，同时氨基己糖浓度升高，但形态学上证实了慢性胰腺炎。这些结果表明，在该实验模型中，胰液体积减少、粘度增加以及氨基己糖浓度同时升高所导致的胰液浓缩会促使慢性胰腺炎的进展。
