Legha S S, Muggia F M
Ann Intern Med. 1977 Nov;87(5):613-21. doi: 10.7326/0003-4819-87-5-613.
A detailed review of the literature was done to define the epidemiology, pathology, clinical features, and treatment of pleural mesothelioma. It appears that pleural mesothelioma accounts for approximately 400 deaths each year in the United States. Asbestos has been definitely implicated in the etiology of this disease. The common clinical features include chest pain, pleural effusion, and radiologic findings of irregular pleural thickening or pleural densities. Therapeutic modalities used in the past have included surgery, radiation therapy, and, more recently, chemotherapy. A combined modality approach to treatment appears more promising.
为明确胸膜间皮瘤的流行病学、病理学、临床特征及治疗方法，我们对相关文献进行了详细综述。在美国，胸膜间皮瘤每年导致约400人死亡。石棉已被明确认定为该疾病病因。常见临床特征包括胸痛、胸腔积液以及胸膜不规则增厚或胸膜致密影的影像学表现。过去使用的治疗方式包括手术、放射治疗，以及最近的化疗。联合治疗方法似乎更具前景。
