Noldy N E, Carlen P L
Playfair Neuroscience Unit, Toronto Hospital Research Institute, Ont., Canada.
Neuropsychobiology. 1997;36(1):53-6. doi: 10.1159/000119361.
The effects of cocaine withdrawal on the latency of the P300 cognitive event-related potential were studied in 36 subjects. All subjects had used cocaine within 48 h of admission to an inpatient unit. P300 was recorded in a traditional auditory oddball paradigm 2 and 6 days following admission. P300 latency decreased from day 2 to day 6 in subjects with a history of intravenous use, but was unchanged in subjects who had only used cocaine orally. The neurotransmitter systems mediating this effect, and the differential cognitive effects of route of administration are discussed.
在36名受试者中研究了可卡因戒断对P300认知事件相关电位潜伏期的影响。所有受试者在入住住院部的48小时内都使用过可卡因。在入院后第2天和第6天，采用传统的听觉oddball范式记录P300。有静脉使用史的受试者的P300潜伏期从第2天到第6天缩短，但仅口服使用可卡因的受试者的P300潜伏期没有变化。文中讨论了介导这种效应的神经递质系统以及给药途径的不同认知效应。
