Biggins C A, MacKay S, Clark W, Fein G
Department of Psychiatry, University of California, San Francisco, USA.
Biol Psychiatry. 1997 Sep 15;42(6):472-85. doi: 10.1016/S0006-3223(96)00425-8.
We examined the effects of cocaine dependence and cocaine and alcohol codependence on the P3A event-related potential component. Ten chronic cocaine-dependent subjects, 10 chronic cocaine and alcohol codependent subjects, and 20 controls were studied in an auditory paradigm that included target, nontarget, and novel rare nontarget conditions. Substance-dependent subjects were abstinent from cocaine and/or alcohol for 2-6 weeks. Eighteen of these subjects (4 chronic cocaine-dependent subjects, 4 chronic cocaine/alcohol codependent subjects, and 10 normal controls) were also studied in an analogous visual paradigm. In the auditory modality, the latency of the P3A response in the novel rare nontarget condition was delayed and its amplitude was reduced in both substance-dependent samples compared to controls. Comparable results were found for the smaller samples studied in the visual modality. These results suggest that chronic cocaine dependence produces deficits in frontal cortex functions.
我们研究了可卡因依赖以及可卡因和酒精共同依赖对P3A事件相关电位成分的影响。在一个包括目标、非目标和新异罕见非目标条件的听觉范式中，对10名慢性可卡因依赖者、10名慢性可卡因和酒精共同依赖者以及20名对照者进行了研究。物质依赖者已戒除可卡因和/或酒精2至6周。其中18名受试者（4名慢性可卡因依赖者、4名慢性可卡因/酒精共同依赖者和10名正常对照者）还在类似的视觉范式中进行了研究。在听觉模式下，与对照相比，在新异罕见非目标条件下，两个物质依赖样本中P3A反应的潜伏期均延迟，其波幅降低。在视觉模式下对较小样本的研究也发现了类似结果。这些结果表明，慢性可卡因依赖会导致额叶皮质功能缺陷。
