Chen J C, Hildebrand H D, Salvian A J, Hsiang Y N, Taylor D C
Department of Surgery, Vancouver Hospital and Health Science Centre, University of British Columbia, Canada.
Cardiovasc Surg. 1997 Apr;5(2):150-6. doi: 10.1016/s0967-2109(97)00003-3.
The purpose of this study was to examine the changing trends in surgical management of patients with abdominal aortic aneurysms at a tertiary care teaching hospital over the past 40 years, by analysis of demographic data, perioperative variables and outcomes on all patients having abdominal aortic aneurysm surgery between 1955 and 1993. Some 1604 abdominal aortic aneurysms were assessed. The annual rate of abdominal aortic aneurysm surgery increased from 17.6 to 67.8 cases per year. The non-ruptured to ruptured abdominal aortic aneurysm ratio increased from 2.4:1 in the first decade to 3.4:1 in the last 5 years. In non-ruptured abdominal aortic aneurysm repairs, the following variables changed over the four decades: patients age over 80 years increased (2.4% to 8.0%; P<0.04), concomitant lower-limb occlusive disease increased (12.2% to 23.7%; P<0.02), prevalence of smaller aneurysms (4-6 cm) increased (16.0% to 54.2%; P<0.0001); intraoperative hypotension decreased (9.0% to 0.7%; P<0.0001), postoperative hemorrhage decreased (8.2% to 0.0%, P<0.0001), postoperative leg ischemia decreased (5.7% to 1.1%; P<0.02) and postoperative amputation rate decreased (3.2% to 0.0%; P<0.03). There was a significant decrease in perioperative mortality (17.0% to 3.4%; P<0.0001). For ruptured aneurysms, early operation (within 1 h of admission) increased from 8.7% to 55.8% (P<0.0001), prevalence of intraoperative hypotension decreased (50.0% to 23.5%; P<0.001), and major venous injury decreased (18.0% to 5.2%; P<0.05). Mortality, however, did not decrease significantly (54.2% to 44.2%; P=0.32). In conclusion, there was a significant decrease in mortality and morbidity associated with non-ruptured abdominal aortic aneurysm repair over the four decades studied. In addition, older patients with smaller aneurysms and more co-morbid conditions were operated on during this period. Mortality for patients operated on for ruptured abdominal aortic aneurysm repair has not changed significantly.
本研究的目的是通过分析1955年至1993年间所有接受腹主动脉瘤手术患者的人口统计学数据、围手术期变量及预后情况,研究一家三级护理教学医院在过去40年里腹主动脉瘤患者外科治疗的变化趋势。共评估了约1604例腹主动脉瘤。腹主动脉瘤手术的年手术率从每年17.6例增至67.8例。未破裂与破裂腹主动脉瘤的比例从第一个十年的2.4:1增至最近5年的3.4:1。在未破裂腹主动脉瘤修复手术中,以下变量在这四十年间发生了变化:80岁以上患者增加(从2.4%增至8.0%;P<0.04),合并下肢闭塞性疾病增加(从12.2%增至23.7%;P<0.02),较小动脉瘤(4 - 6厘米)的患病率增加(从16.0%增至54.2%;P<0.0001);术中低血压减少(从9.0%降至0.7%;P<0.0001),术后出血减少(从8.2%降至0.0%,P<0.0001),术后腿部缺血减少(从5.7%降至1.1%;P<0.02),术后截肢率降低(从3.2%降至0.0%;P<0.03)。围手术期死亡率显著降低(从17.0%降至3.4%;P<0.0001)。对于破裂动脉瘤,早期手术(入院后1小时内)从8.7%增至55.8%(P<0.0001),术中低血压患病率降低(从50.0%降至23.5%;P<0.001),主要静脉损伤减少(从18.0%降至5.2%;P<0.05)。然而,死亡率未显著降低(从54.2%降至44.2%;P = 0.32)。总之,在所研究的四十年间,未破裂腹主动脉瘤修复相关的死亡率和发病率显著降低。此外,在此期间,对年龄较大、动脉瘤较小且合并症较多的患者进行了手术。破裂腹主动脉瘤修复手术患者的死亡率没有显著变化。