Kozlowska E, Kopeć-Szlezak J, Drela N, Michur H, Izdebska-Szymona K
Department of Immunology, Warsaw University, Poland.
Ecotoxicol Environ Saf. 1997 Jun;37(1):10-6. doi: 10.1006/eesa.1996.1513.
The toxic effect of Silesian air pollutants to mouse organs was examined. Histological changes were found in the examined lymphoid organs (thymus, spleen) as well nonlymphoid organs (liver, kidneys). The alterations in weight indexes of lymphoid organs were also observed. Considerable changes in cellularity, weight index, and histology of the thymus in the mice exposed to air pollutants suggest the atrophy of this organ, which may lead to extrathymic T-cell differentiation and even acceleration of thymocytes maturation, which may lead to certain allergic or auto-immune pollutants of all investigated mouse organs in the following order: thymus, liver, kidneys, and spleen.
研究了西里西亚空气污染物对小鼠器官的毒性作用。在所检查的淋巴器官（胸腺、脾脏）以及非淋巴器官（肝脏、肾脏）中发现了组织学变化。还观察到了淋巴器官重量指数的改变。暴露于空气污染物的小鼠胸腺的细胞数量、重量指数和组织学发生了显著变化，表明该器官萎缩，这可能导致胸腺外T细胞分化，甚至加速胸腺细胞成熟，这可能依次导致所有被研究小鼠器官出现某些过敏或自身免疫反应：胸腺、肝脏、肾脏和脾脏。
