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Antimicrob Agents Chemother. 1977 Oct;12(4):548-9. doi: 10.1128/AAC.12.4.548.
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Is Penicillin Plus Gentamicin Synergistic Against Sessile Group B Streptococcal Isolates? An Study With an Experimental Model of Foreign-Body Infection.青霉素加庆大霉素对固着性B族链球菌分离株有协同作用吗？一项关于异物感染实验模型的研究。
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Aminoglycoside therapy: current and prospective uses.氨基糖苷类药物治疗：当前及潜在用途。
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Curative effects of tobramycin or gentamicin therapy on mouse arthritis caused by Mycoplasma pulmonis.妥布霉素或庆大霉素治疗鼠肺支原体引起的小鼠关节炎的疗效。
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本文引用的文献

1
Antibacterial activity of synovial fluid during therapy of septic arthritis.化脓性关节炎治疗期间滑液的抗菌活性。
Arthritis Rheum. 1971 Jan-Feb;14(1):96-104. doi: 10.1002/art.1780140112.
2
Antibiotic concentrations in septic joint effusions.
N Engl J Med. 1971 Feb 18;284(7):349-53. doi: 10.1056/NEJM197102182840702.
3
Gentamicin and carbenicillin penetration into the septic joint.庆大霉素和羧苄青霉素在感染关节中的渗透情况。
N Engl J Med. 1971 Jul 15;285(3):178-9. doi: 10.1056/nejm197107152850318.
4
Comparative clinical study of tobramycin and gentamicin.妥布霉素与庆大霉素的对比临床研究
Antimicrob Agents Chemother. 1974 Feb;5(2):133-8. doi: 10.1128/AAC.5.2.133.
5
Transport of gentamicin into synovial fluid.
JAMA. 1974 Apr 29;228(5):607.
6
Ampicillin and kanamycin concentrations in joint fluid.
Clin Pharmacol Ther. 1971 Sep-Oct;12(5):858-63. doi: 10.1002/cpt1971125858.

庆大霉素和妥布霉素在滑液中的渗透情况。

Gentamicin and tobramycin penetration into synovial fluid.

作者信息

Dee T H, Kozin F

出版信息

Antimicrob Agents Chemother. 1977 Oct;12(4):548-9. doi: 10.1128/AAC.12.4.548.

DOI:10.1128/AAC.12.4.548
PMID:921252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429965/
Abstract

The penetration of gentamicin and tobramycin into the synovial fluid of 12 patients with nontraumatic joint effusions was studied. Simultaneous serum and synovial fluid specimens taken after the intramuscular or intravenous administration of an antimicrobial agent were assayed. Synovial fluid levels of antibiotic were >50% of serum levels in all subjects studied. In five patients, synovial fluid levels were equal to or exceeded simultaneous serum values. These results suggest that intra-articular injection of aminoglycoside antibiotics is not necessary in the treatment of infectious arthritis.

摘要

对12例非创伤性关节积液患者的庆大霉素和妥布霉素向滑液中的渗透情况进行了研究。在肌肉注射或静脉注射抗菌药物后，同时采集血清和滑液标本进行检测。在所有研究对象中，抗生素的滑液水平均>血清水平的50%。在5例患者中，滑液水平等于或超过了同时的血清值。这些结果表明，在感染性关节炎的治疗中，关节腔内注射氨基糖苷类抗生素没有必要。