庆大霉素和妥布霉素在滑液中的渗透情况。
Gentamicin and tobramycin penetration into synovial fluid.
作者信息
Dee T H, Kozin F
出版信息
Antimicrob Agents Chemother. 1977 Oct;12(4):548-9. doi: 10.1128/AAC.12.4.548.
Abstract
The penetration of gentamicin and tobramycin into the synovial fluid of 12 patients with nontraumatic joint effusions was studied. Simultaneous serum and synovial fluid specimens taken after the intramuscular or intravenous administration of an antimicrobial agent were assayed. Synovial fluid levels of antibiotic were >50% of serum levels in all subjects studied. In five patients, synovial fluid levels were equal to or exceeded simultaneous serum values. These results suggest that intra-articular injection of aminoglycoside antibiotics is not necessary in the treatment of infectious arthritis.
摘要
对12例非创伤性关节积液患者的庆大霉素和妥布霉素向滑液中的渗透情况进行了研究。在肌肉注射或静脉注射抗菌药物后，同时采集血清和滑液标本进行检测。在所有研究对象中，抗生素的滑液水平均>血清水平的50%。在5例患者中，滑液水平等于或超过了同时的血清值。这些结果表明，在感染性关节炎的治疗中，关节腔内注射氨基糖苷类抗生素没有必要。
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本文引用的文献
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