Malvy D J, Arnaud J, Burtschy B, Sommelet D, Leverger G, Dostalova L, Amédée-Manesme O
INSERM U056, Hospital Center of Bicêtre, France.
Med Pediatr Oncol. 1997 Sep;29(3):213-7. doi: 10.1002/(sici)1096-911x(199709)29:3<213::aid-mpo9>3.0.co;2-g.
Serum antioxidant vitamins A (retinol) and E (alpha-tocopherol), beta-carotene, zinc, and selenium, and cholesterol and related proteins for 170 children with newly diagnosed malignancy were measured at diagnosis and 6 months after initiation of treatment, and compared with those of 632 cancer-free controls. Incident cancer cases and controls were 1-16 years old and recruited between 1986 and 1989. At diagnosis, age- and sex-adjusted serum concentrations of retinol, beta-carotene, zinc, and alpha-tocopherol were significantly inversely associated with cancer. No significant decreases in mean values were observed at 6 month, except for the alpha-tocopherol-to-cholesterol ratio in patients with bone tumors and serum zinc in bone tumors and central nervous system malignancies. An increase during the period of treatment was found for retinol and selenium in leukemia patients. beta-carotene was maintained at the initial concentrations determined prior to therapy. These findings provide further information about micronutrient requirements in children with cancer.
对170名新诊断为恶性肿瘤的儿童在诊断时及开始治疗6个月后测定了血清抗氧化维生素A（视黄醇）、E（α-生育酚）、β-胡萝卜素、锌、硒以及胆固醇和相关蛋白质，并与632名无癌对照者进行了比较。新发病例和对照者年龄在1至16岁之间，于1986年至1989年招募。诊断时，经年龄和性别调整的视黄醇、β-胡萝卜素、锌和α-生育酚血清浓度与癌症显著负相关。除骨肿瘤患者的α-生育酚与胆固醇比值以及骨肿瘤和中枢神经系统恶性肿瘤患者的血清锌外，6个月时未观察到平均值有显著下降。白血病患者治疗期间视黄醇和硒有所增加。β-胡萝卜素维持在治疗前测定的初始浓度。这些发现为癌症患儿的微量营养素需求提供了进一步信息。
