Rebhandl W, Felberbauer F X, Paya K, Rami B, Bancher-Todesca D, Bieglmayer C, Horcher E
Division of Pediatric Surgery, University of Vienna Medical School, Austria.
Med Pediatr Oncol. 1997 Sep;29(3):218-21. doi: 10.1002/(sici)1096-911x(199709)29:3<218::aid-mpo10>3.0.co;2-9.
Measurement of serum concentrations of tissue polypeptide-specific Antigen (TPS) has been demonstrated to the useful in diagnosis and monitoring of adult epithelial tumors. So far, no data have been available on normal or pathologic TPS values in children. Therefore, the present study was designed to evaluate the normal values of TPS in childhood. Using a commercial enzyme linked immunosorbent assay (ELISA) kit, serum TPS was determined in 361 healthy children. Median (M) TPS was found to be 107 U/l at birth (n = 124). By the end of the first week, the value rose to M = 150 U/l (n = 68) and then continuously decreased with age (1 week-1 year, n = 45, M = 88 U/l; 1-7 years, n = 75, M = 51 U/l) until reaching the adult level (8-18 years, n = 49, M = 34 U/l). Additionally, the serum TPS values of 45 mothers right after delivery (M = 161 U/l) were assessed, and there was no correlation to the marker levels determined in the cord blood of their children. The age-dependent distribution of serum TPS in healthy children must be taken into account in the clinical application of this tumor marker.
血清组织多肽特异性抗原（TPS）浓度的测定已被证明在成人上皮性肿瘤的诊断和监测中有用。到目前为止，尚无关于儿童正常或病理TPS值的数据。因此，本研究旨在评估儿童期TPS的正常值。使用商用酶联免疫吸附测定（ELISA）试剂盒，对361名健康儿童测定血清TPS。出生时（n = 124）中位（M）TPS为107 U/l。到第一周结束时，该值升至M = 150 U/l（n = 68），然后随年龄持续下降（1周 - 1岁，n = 45，M = 88 U/l；1 - 7岁，n = 75，M = 51 U/l），直至达到成人水平（8 - 18岁，n = 49，M = 34 U/l）。此外，评估了45名母亲产后即刻的血清TPS值（M = 161 U/l），且与她们孩子脐带血中测定的标志物水平无相关性。在该肿瘤标志物的临床应用中，必须考虑健康儿童血清TPS的年龄依赖性分布。
