波动泵全人工心脏的研发。

Development of the undulation pump total artificial heart.

作者信息

Abe Y, Chinzei T, Isoyama T, Ono T, Mochizuki S, Mabuchi K, Baba K, Matsuura H, Sun Y P, Kouno A, Atsumi K, Fujimasa I, Imachi K

机构信息

Institute of Medical Electronics, Faculty of Medicine, University of Tokyo, Japan.

出版信息

Artif Organs. 1997 Jul;21(7):665-9. doi: 10.1111/j.1525-1594.1997.tb03719.x.

DOI:10.1111/j.1525-1594.1997.tb03719.x

PMID:9212936

Abstract

The undulation pump is a small size continuous flow displacement type blood pump that has been developed for an artificial heart. Using undulation pumps, 2 types of implantable total artificial hearts (TAHs), the undulation pump TAH (UPTAH) type 1 (UPTAH 1) and UPTAH type 2 (UPTAH 2) were developed. Both UPTAHs were designed to be small enough to implant into the chest of a goat, the experimental animal. UPTAH 1 could be reduced in size to 75 mm in diameter and 78 mm in length. The weight was 520 g. UPTAH 2 could be reduced in size to 75 mm in diameter and 80 mm in length. The weight was 650 g. UPTAH 2 could be tested in an animal experiment using an adult female goat weighing 52.3 kg. The UPTAH 2 could be implanted successfully into the goat's chest with a good fit. The goat stood after the surgery and extubation and survived for 3 h and 40 min; thus, the potential of the UPTAH for a practical implantable TAH was demonstrated.

摘要

波动泵是一种为人工心脏开发的小尺寸连续流置换型血泵。利用波动泵，开发了两种可植入式全人工心脏（TAH），即波动泵TAH（UPTAH）1型（UPTAH 1）和UPTAH 2型（UPTAH 2）。两种UPTAH的设计尺寸都小到足以植入实验动物山羊的胸腔。UPTAH 1的尺寸可减小到直径75毫米、长度78毫米。重量为520克。UPTAH 2的尺寸可减小到直径75毫米、长度80毫米。重量为650克。UPTAH 2可在一只体重52.3千克的成年雌性山羊身上进行动物实验。UPTAH 2能够成功植入山羊胸腔且贴合良好。山羊在手术和拔管后站立起来，并存活了3小时40分钟；因此，证明了UPTAH作为一种实用的可植入式TAH的潜力。