Yamada T, Mizumoto A, Satoh M, Haga N, Itoh Z
Gastrointestinal Research Laboratory, Gunma University, Maebashi, Japan.
Peptides. 1997;18(5):673-80. doi: 10.1016/s0196-9781(97)00132-0.
The role of muscarinic receptor subtype(s) in the control of gastric phase III contractions and motilin release was determined in dogs. Pirenzepine (226 nmol/kg/h) shortened the phase III cycle, causing an early increase in plasma motilin concentrations. Both AF-DX116BS and 4-DAMP inhibited the occurrence of spontaneous and motilin-induced phase III contractions, and 4-DAMP also inhibited the spontaneous increase in plasma motilin concentration. Only 4-DAMP inhibited carbachol-induced motilin release in perifused duodenal mucosal cells. In conclusion, M1 receptors are involved in the indirect inhibition of motilin release. Motilin-induced contractions are mediated mainly by M3 receptors and partly by M2 receptors, and M3 receptors are present in motilin-producing cells.
在犬类中确定了毒蕈碱受体亚型在控制胃Ⅲ相收缩和胃动素释放中的作用。哌仑西平（226 nmol/kg/h）缩短了Ⅲ相周期，导致血浆胃动素浓度早期升高。AF-DX116BS和4-DAMP均抑制自发性和胃动素诱导的Ⅲ相收缩的发生，且4-DAMP还抑制血浆胃动素浓度的自发性升高。仅4-DAMP抑制卡巴胆碱诱导的灌流十二指肠黏膜细胞中胃动素的释放。总之，M1受体参与胃动素释放的间接抑制。胃动素诱导的收缩主要由M3受体介导，部分由M2受体介导，且M3受体存在于产生胃动素的细胞中。
