Krige D, Mills H R, Berrie E L, Doherty N C, Jones D K, Ryan C A, Davies H, Myint S, McCance D J, Layton G T, French T J
British Biotech Pharmaceuticals Ltd., Oxford, UK.
Virus Res. 1997 Jun;49(2):187-91. doi: 10.1016/s0168-1702(97)01469-x.
The majority of condylomata acuminata (anogenital warts) are caused by infection with Human Papilloma Virus type 6 (HPV-6). We have sequenced the HPV-6 early genes, E1-E4, E6 and E7 from wart biopsy DNA samples sourced from the UK and USA and derived a consensus sequence for these genes and the proteins they encode. When compared to the prototype HPV-6b sequence, published over 12 years ago, the E1-E4 consensus sequence showed 3/91 (3.3%) amino acid changes, the E6 consensus sequence showed 1/150 (0.7%) changes and the E7 consensus sequence showed 1/98 (1.0%) changes. Since many of the early gene sequences from biopsy material were more similar to the HPV-6a subtype than HPV-6b, this data supports the use of HPV-6a as the HPV-6 prototype.
